Work Packages

WP1: Tumour-selective antibody-based targeting of immune checkpoints to (re)activate anticancer immunity

In WP1 we aim to develop new tumour-targeted drugs to selectively block key innate and adaptive immune checkpoints in the tumour micro-environment. Specifically, various negative regulators of innate immunity, such as PD-1, TIM-3 and CD47, have been described and various newly identified checkpoints are emerging.

WP2: Development of novel costimulatory antibody fusion proteins with tumour-restricted FcR-independent activity

In WP2 we aim to develop new tumour-targeted antibodies and antibody fusion proteins to selectively activate key co-stimulatory receptors of the TNFRSF in the tumour micro-environment. Herewith, local optimal co-stimulation of T-cell is provided to ensure induction and execution of anticancer immune response in the absence of systemic immune-related side-effects.

WP3: Training activities

In WP3, we aim to achieve our training Objective to deliver researchers with interdisciplinary and intersectoral expertise. Hereto, I-DireCT provides a versatile training programme that addresses academic and industrial expertise and personal skills. The training programme encompasses: (1) original research projects as the core of doctoral education, performed at the host institution and through secondments; (2) formal training via courses and workshops by each institution; (3) original training components offered by the consortium network; and (4) components accessed by ESRs through existing outside-network activities.

WP4: Outreach & Dissemination

The overall objective of WP4 is to ensure coherent external communication of I-DireCT activities, progress and achievements and the optimal management and exploitation of research outcomes and resulting Intellectual Property (IP). Objectives are to 1. create visibility and encourage project outreach; 2. coordinate dissemination, knowledge, and innovation activities in a specific dissemination strategy; 3. foster innovation and exploitation of results.

WP5: Management

The objectives of WP5 are to manage and coordinate the I-DireCT consortium by:

  1. Providing optimal orientation to all partners through set-up of effective management & communication structures, guidance and support.
  2. providing transparency to consortium partners and EC through proper project documentation.
  3. ensuring timely and qualitative achievement of project results through scientific and administrative coordination.
WP6: Ethics requirements

The objective is to ensure compliance with the 'ethics requirements' set out in this work package.