Medler J, Kucka K, Melo Galegos V, Zhang T, von Rotenhan S, Ulrich J, Bremer E, Hudecek M, Beilhack A, Wajant H. (2021).
CD40- and 41BB-specific antibody fusion proteins with PDL1 blockade-restricted agonism.
Theranostics. 2022; 12(4):1486-1499.
Cendrowicz E, Jacob L, Greenwald S, Tamir A, Pecker I, Tabakman R, Ghantous L, Tamir L, Kahn R, Avichzer J, Aronin A, Amsili S, Zorde-Khvalevsky E, Gozlan Y, Vlaming M, Huls G, van Meerten T, Elhalel Dranitzki M, Foley-Comer A, Pereg Y, Peled A, Chajut A, Bremer E.
DSP107 combines inhibition of CD47/SIRPα axis with activation of 4-1BB to trigger anticancer immunity.
Journal of Experimental and Clinical Research (in press).
International Journal of Molecular Sciences. 2020, 21(21), 7820.
Jimena Álvarez Freile J, Yuzhu Qi, Lisa Jacob, Maria Franceskin Lobo, Harm Jan Lourens, Gerwin Huls, Edwin Bremer.
A luminescence-based method to assess antigen presentation and antigen-specific T cell responses for in vitro screening of immunomodulatory checkpoints and therapeutics.
Front. Immunol., Volume 14, 25 July 2023.
Vinicio Melo, Levi Collin Nelemans, Martijn Vlaming, Harm Jan Lourens, Valerie R. Wiersma, Vrouyr Bilemjian, Gerwin Huls, Marco de Bruyn, Edwin Bremer.
EGFR-selective activation of CD27 co-stimulatory signaling by a bispecific antibody enhances anti-tumor activity of T cells.
Front. Immunol., Volume 14, 20 July 2023.
Ghizlane Choukrani, Nienke Visser, Natasha Ustyanovska Avtenyuk, Mirjam Olthuis, Glenn Marsman, Emanuele Ammatuna, Harm Jan Lourens, Toshiro Niki, Gerwin Huls, Edwin Bremer and Valerie R. Wiersma.
Galectin-9 has non-apoptotic cytotoxic activity towards Acute Myeloid Leukemia independent of cytarabine resistance.
Cell Death Discovery, 2023 Jul 6;9(1):228.
Martijn Vlaming, Vrouyr Bilemjian, Jimena Álvarez Freile, Vinicio Melo Galegos, Annechien Plat, Gerwin Huls, Hans W Nijman, Marco de Bruyn, Edwin Bremer.
Tumor infiltrating CD8/CD103/TIM-3-expressing lymphocytes in epithelial ovarian cancer co-express CXCL13 and associate with improved survival.
Front Immunol. 2022 Oct 21;13:1031746.
Vrouyr Bilemjian, Martijn R. Vlaming, Jimena Álvarez Freile, Gerwin Huls, Marco De Bruyn*, Edwin Bremer*.
The novel immune checkpoint GPR56 is predominantly expressed and selectively upregulated in tumor-infiltrating and tumor-reactive lymphocytes.
Cancers (Basel). 2022.
Jimena Álvarez Freile, Natasha Ustyanovska Avtenyuk, Macarena González Corrales, Harm Jan Lourens, Gerwin Huls, Tom van Meerten, Ewa Cendrowicz, and Edwin Bremer.
CD24 is a potential immunotherapeutic target for Mantle Cell Lymphoma.
Biomedicines. 2022, 10(5), 1175.
Vinicio Melo Galegos, Edwin Bremer, John Martin.
Towards immunotherapy-induced normalization of the tumor microenvironment.
Frontiers in Cell and Developmental Biology. 2022. Vol 10.
Medler J, Kucka K, Melo Galegos V, Zhang T, von Rotenhan S, Ulrich J, Bremer E, Hudecek M, Beilhack A, Wajant H. (2021).
CD40- and 41BB-specific antibody fusion proteins with PDL1 blockade-restricted agonism.